Destroying the crystals is possible only after you’ve obtained a certain artifact.

The image above shows an exemplary deposit of eridium.

You will find yourself inVault of the Rampager- search the area forEridian Resonator, a quest item.

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This will allow you to gathereridium- a premium currency that can be spent at Crazy Earl in the Sanctuary.

Aside from eridium deposits, you’re able to also destroycrystals that encompass chests(screenshot above).

you’re free to kick off the chest after getting rid of all crystals.

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Eridium chests hold rare loot.

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Borderlands 3